Search on: ISLETS OF LANGERHANS 
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Descriptor English:   Islets of Langerhans 
Descriptor Spanish:   Islotes Pancreáticos 
Descriptor Portuguese:   Ilhotas Pancreáticas 
Synonyms English:   Islands of Langerhans
Islet Cells
Nesidioblasts
Pancreas, Endocrine
Pancreatic Islets  
Tree Number:   A03.734.414
A06.407.414
Definition English:   Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN. 
Indexing Annotation English:   do not confuse with LANGERHANS CELLS (skin); neoplasms = ADENOMA, ISLET CELL or CARCINOMA, ISLET CELL or their specifics
Entry Combination - descr/qualif English:   Islets of Langerhans/transplantation use Islets of Langerhans Transplantation
 
History Note English:   91; was ISLANDS OF LANGERHANS 1963-90 
Allowable Qualifiers English:  
abnormalities anatomy & histology
blood supply chemistry
cytology drug effects
embryology enzymology
growth & development immunology
injuries innervation
metabolism microbiology
pathology physiology
physiopathology parasitology
radiography radiation effects
radionuclide imaging secretion
surgery ultrastructure
ultrasonography virology
Record Number:   29211 
Unique Identifier:   D007515 

Occurrence in VHL: 		 

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